series of 2-semicarbazonomethyl-4,5-methylenedioxyphenylacetic acids (12–19) were synthesized and tested as anticonvulsant agents in DBA/2 mice against sound-induced seizures and the results compared to those previously reported for the corresponding methyl esters (4-11). The new compounds possess anticonvulsant properties lower than those of 4–11, but, in some instances, comparable to that of GYKI 52466, a well-known noncompetitive AMPA receptor antagonist.
Synthesis of 2-semicarbazonomethyl-4,5-methylenedioxyphenylacetic acids as anticonvulsant agents
MICALE, Nicola;ZAPPALA', Maria;GRASSO, Silvana
2005-01-01
Abstract
series of 2-semicarbazonomethyl-4,5-methylenedioxyphenylacetic acids (12–19) were synthesized and tested as anticonvulsant agents in DBA/2 mice against sound-induced seizures and the results compared to those previously reported for the corresponding methyl esters (4-11). The new compounds possess anticonvulsant properties lower than those of 4–11, but, in some instances, comparable to that of GYKI 52466, a well-known noncompetitive AMPA receptor antagonist.File in questo prodotto:
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