The effects of repeated oral administration of 2.5–20 mg/kg of two Citrusaurantium fruit extracts standardized to different concentrations of synephrine (4 and 6%, respectively) on food intake, body weight gain, arterial blood pressure, electrocardiogram (ECG) and mortality have been investigated in the rat. C. aurantium administration significantly reduced food intake and body weight gain. However, mortality (not observed in controls) was present in all C. aurantium treated groups. Arterial blood pressure was not modified, but ECG alterations (ventricular arhythmias with enlargement of QRS complex) were evident in animals treated with both extracts. Our data indicate that, in the rat, antiobesityeffects of C. aurantium are accompanied by toxiceffects probably due to cardiovascular toxicity.
Antiobesity and cardiovascular toxic effects of citrus aurantium extracts in the rat: a preliminary report
CALAPAI, Gioacchino;SAITTA, Antonino;
1999-01-01
Abstract
The effects of repeated oral administration of 2.5–20 mg/kg of two Citrusaurantium fruit extracts standardized to different concentrations of synephrine (4 and 6%, respectively) on food intake, body weight gain, arterial blood pressure, electrocardiogram (ECG) and mortality have been investigated in the rat. C. aurantium administration significantly reduced food intake and body weight gain. However, mortality (not observed in controls) was present in all C. aurantium treated groups. Arterial blood pressure was not modified, but ECG alterations (ventricular arhythmias with enlargement of QRS complex) were evident in animals treated with both extracts. Our data indicate that, in the rat, antiobesityeffects of C. aurantium are accompanied by toxiceffects probably due to cardiovascular toxicity.Pubblicazioni consigliate
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