A series of 3-(alkylcarbamoyl)-2-aryl-1,2-dihydro-6,7-(methylenedioxy)-3H-quinazolin-4-ones, compounds 3 ± 6, were synthesized, and screened as anticonvulsant agents in DBA/2 mice against sound-induced seizure (Table). The new compounds were found to display anticonvulsant properties inferior to those of the known dehydro congeners 1 and 2. The binding affinities of 1 ± 6 at the AMPA and NMDA receptors were also evaluated.
Synthesis of novel 3-alkylcarbamoyl-2-aryl-1,2-dihydro-6,7-methylenedioxy-3H-quinazolin-4-ones as anticonvulsant agents
MICALE, Nicola;GRASSO, Silvana;ZAPPALA', Maria;
2006-01-01
Abstract
A series of 3-(alkylcarbamoyl)-2-aryl-1,2-dihydro-6,7-(methylenedioxy)-3H-quinazolin-4-ones, compounds 3 ± 6, were synthesized, and screened as anticonvulsant agents in DBA/2 mice against sound-induced seizure (Table). The new compounds were found to display anticonvulsant properties inferior to those of the known dehydro congeners 1 and 2. The binding affinities of 1 ± 6 at the AMPA and NMDA receptors were also evaluated.File in questo prodotto:
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