Abstract E-rosette formation is not modified by preincubation of lymphocytes with prostaglandins (PGs) E1, F1 alpha, and F2 alpha. On the contrary, short preincubation with PGE2 affects active rosette-forming cells (Ea-RFC) and, only slightly, total RFC. This effect appears to be dose-dependent and relatively temperature-independent; it does not require calcium ions. Incubation with a fraction enriched in late RFC showed that PGE2 does not affect late rosette formation. It is postulated that PGE2 may redistribute surface receptors for sheep erythrocytes on T lymphocyte membranes. Thus, sensitivity to PGE2 may be considered another difference between early and late RFC.
Interaction between Prostaglandins and human T lymphocytes : effect of PGE2 on E-receptor expression
TETI, Diana;MISEFARI, Aldo;SOFO, Vincenza;FIMIANI, Vincenzo;
1980-01-01
Abstract
Abstract E-rosette formation is not modified by preincubation of lymphocytes with prostaglandins (PGs) E1, F1 alpha, and F2 alpha. On the contrary, short preincubation with PGE2 affects active rosette-forming cells (Ea-RFC) and, only slightly, total RFC. This effect appears to be dose-dependent and relatively temperature-independent; it does not require calcium ions. Incubation with a fraction enriched in late RFC showed that PGE2 does not affect late rosette formation. It is postulated that PGE2 may redistribute surface receptors for sheep erythrocytes on T lymphocyte membranes. Thus, sensitivity to PGE2 may be considered another difference between early and late RFC.Pubblicazioni consigliate
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