Objective: To compare danazol and gestrinone treatment as preoperative endometrial preparation for operative hysteroscopy. Design: Prospective,randomized clinical study. Setting: University department of gynecological, obstetrical sciences and reproductive medicine. Patient(s): One hundred thirty-five patients with endouterine pathologies (endometrial polyps, submucous myoma, septate uterus). Intervention(s): Patients pretreated with gestrinone (n= 68) and with danazol (n= 67) underwent operative hysteroscopy. Main Outcome Measure(s): Endometrial response to the medical pretreatment, side effects, procedure time, intraoperative bleeding, infusion volume, patient satisfaction. Result(s): Side effects were infrequent in both groups, though the patients personal satisfaction was in favor of gestrinone. The rate of endometrial response was higher for the gestrinone group (97.1% vs 83.6%). Operative time (mean +/- SD) was 12 +/- 1.8 and 15.2 +/- 1.9 minutes for the gestrinone and danazol groups, respectively. The gestrinone group showed a lower incidence of moderate bleeding ( 3% vs 22.4% ) and a lower infusion volume ( 2.100 +/- 200 mL vs 2.400 +/- 250 mL). Regarding cervical dilatation time, no significant difference was found between the two groups (1.6 +/- 0.3 minutes vs. 1.5 +/- 0.4 minutes ). Conclusion(s): Both treatments are good ways to prepare the endometrium for operative hysteroscopy. However, the data suggest that gestrinone pretreatment is preferable to danazol ( Fertil Steril 2006:85:1027-31. 2006 by American Society for Reproductive Medicine.)

Gestrinone versus danazol as preoperative treatment for hysteroscopic surgery: a prospective, randomized evaluation.

TRIOLO, Onofrio;DE VIVO, ANTONIO;BENEDETTO, Vincenzo;ANTICO, Francesco
2006-01-01

Abstract

Objective: To compare danazol and gestrinone treatment as preoperative endometrial preparation for operative hysteroscopy. Design: Prospective,randomized clinical study. Setting: University department of gynecological, obstetrical sciences and reproductive medicine. Patient(s): One hundred thirty-five patients with endouterine pathologies (endometrial polyps, submucous myoma, septate uterus). Intervention(s): Patients pretreated with gestrinone (n= 68) and with danazol (n= 67) underwent operative hysteroscopy. Main Outcome Measure(s): Endometrial response to the medical pretreatment, side effects, procedure time, intraoperative bleeding, infusion volume, patient satisfaction. Result(s): Side effects were infrequent in both groups, though the patients personal satisfaction was in favor of gestrinone. The rate of endometrial response was higher for the gestrinone group (97.1% vs 83.6%). Operative time (mean +/- SD) was 12 +/- 1.8 and 15.2 +/- 1.9 minutes for the gestrinone and danazol groups, respectively. The gestrinone group showed a lower incidence of moderate bleeding ( 3% vs 22.4% ) and a lower infusion volume ( 2.100 +/- 200 mL vs 2.400 +/- 250 mL). Regarding cervical dilatation time, no significant difference was found between the two groups (1.6 +/- 0.3 minutes vs. 1.5 +/- 0.4 minutes ). Conclusion(s): Both treatments are good ways to prepare the endometrium for operative hysteroscopy. However, the data suggest that gestrinone pretreatment is preferable to danazol ( Fertil Steril 2006:85:1027-31. 2006 by American Society for Reproductive Medicine.)
2006
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11570/1889872
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