The synthesis of carbocyclic 2'-oxa-3'-aza-nucleosides has been described, based on the 1,3-dipolar cycloaddition of a new phosphonated nitrone with vinyl acetate followed by coupling with silylated nucleobases. The obtained compounds have been evaluated for their ability to inhibit the reverse transcriptase of avian myeloblastosis retrovirus: no significant activity has been observed.

Synthesis and biological evaluation of phosphonated carbocyclic 2-oxa-3 '-aza-nucleosides

IANNAZZO, Daniela;PIPERNO, Anna;ROMEO, Roberto;ROMEO, Giovanni;
2006-01-01

Abstract

The synthesis of carbocyclic 2'-oxa-3'-aza-nucleosides has been described, based on the 1,3-dipolar cycloaddition of a new phosphonated nitrone with vinyl acetate followed by coupling with silylated nucleobases. The obtained compounds have been evaluated for their ability to inhibit the reverse transcriptase of avian myeloblastosis retrovirus: no significant activity has been observed.
2006
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11570/1891776
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