INTRODUCTION AND AIMS: Serum advanced oxidation protein products (AOPP) are new markers of protein damage induced by oxidative stress. Hypertension and especially chronic renal failure are characterized by inflammatory and metabolic changes with consequent alteration in reduction-oxidative (redox) mechanisms. We evaluate serum levels of AOPP in a cohort of patients with chronic renal failure (CRF) and hypertension (HTN) and compared with a control healthy population. METHODS: 90 patients were enrolled: 44 (31M/13F) with CRF (stage 2-5), median age 66 +/-15, and 18 (12M/6F) with HTN, without CRF, median age 63 +/-12, and 28 healthy controls, median age 65 +/-16. Patients with other metabolic disease such as diabetes etc, were excluded. Determination of advanced AOPP was based on spectrophotometric method detection. RESULTS: Serum level of AOPP were increased significantly in CRF group compared with the control groups (135 +/-67; p<0.001) and HTN group (205+/-120; p<0.001). In patients with HTN without CRF, serum levels of AOPP were increased significantly compared with the control groups (p<0.02). A further classification of patients with renal dysfunction in groups according CRF stages, we observed: patients with stage IV and V had AOPP serum levels, on average, higher (219 +/-142) compared with patients stage III (204 +/-99) and even more in patients with stage II and I (182 +/-98). CONCLUSIONS: Our result shows that, both CRF and HTN are conditions characterized by a significant oxidative stress., that in patients with CRF increases with declining of renal function. AOPP serum level are good marker to evaluate in a rapidly, simply and cheap way, the degree of oxidative stress in subjects with CRF and HT typically at higher cardiovascular risk.

OXIDATIVE STRESS IN CHRONIC RENAL FAILURE AND HYPERTESION: ROLE OF ADVANCED OXIDATION PROTEIN PRODUCTS (AOPP)

SANTORO, Domenico;CACCAMO, Daniela;SAVICA, Vincenzo;IENTILE, Riccardo;BELLINGHIERI, Guido
2011-01-01

Abstract

INTRODUCTION AND AIMS: Serum advanced oxidation protein products (AOPP) are new markers of protein damage induced by oxidative stress. Hypertension and especially chronic renal failure are characterized by inflammatory and metabolic changes with consequent alteration in reduction-oxidative (redox) mechanisms. We evaluate serum levels of AOPP in a cohort of patients with chronic renal failure (CRF) and hypertension (HTN) and compared with a control healthy population. METHODS: 90 patients were enrolled: 44 (31M/13F) with CRF (stage 2-5), median age 66 +/-15, and 18 (12M/6F) with HTN, without CRF, median age 63 +/-12, and 28 healthy controls, median age 65 +/-16. Patients with other metabolic disease such as diabetes etc, were excluded. Determination of advanced AOPP was based on spectrophotometric method detection. RESULTS: Serum level of AOPP were increased significantly in CRF group compared with the control groups (135 +/-67; p<0.001) and HTN group (205+/-120; p<0.001). In patients with HTN without CRF, serum levels of AOPP were increased significantly compared with the control groups (p<0.02). A further classification of patients with renal dysfunction in groups according CRF stages, we observed: patients with stage IV and V had AOPP serum levels, on average, higher (219 +/-142) compared with patients stage III (204 +/-99) and even more in patients with stage II and I (182 +/-98). CONCLUSIONS: Our result shows that, both CRF and HTN are conditions characterized by a significant oxidative stress., that in patients with CRF increases with declining of renal function. AOPP serum level are good marker to evaluate in a rapidly, simply and cheap way, the degree of oxidative stress in subjects with CRF and HT typically at higher cardiovascular risk.
2011
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11570/1942246
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact