We studied, in dyslipidemic patients, the correlation between fibrinogen, plasminogen and antithrombin III (AT III) plasma levels and vascular disease (VD), to evaluate a more indicative aspects in relation not only with vascular damage but also with the localization of the vascular district involved. 273 dyslipidemic non diabetics subjects, of which 63 with VD and 174 without vascular complication were examined. Of 63 VD patients (mean age 54.4+13.0, 38 male and 25 female) 34 showed coronary heart disease (CHD), 21 cerebrovascular disease (CVD) and 8 peripheral vascular disease (PVD), the remaining 174 subjects (mean age 43.6±13.9, 95 male and 79 female) were studied as control (C). Fibrinogen (coagulative meth.) plasminogen and ATIII (immunolasernefelometric meth.) levels and fibrinogen/plasminogen ratio were performed. A fibrinogen increase correlated with age but not with sex was observed in all patients. VD subjects showed a significative rise of fibrinogen (p<0.00001) respect to C (398.2± 101.1 vs 328.5187.7 mg/dl) whereas there was no difference in plasminogen and ATIII levels between VD and C subjects. Fibrinogen/plasminogen ratio was significantly higher (p<0.00001) in VD than in C subjects (3.34±1.14 vs 2.66±0.78). In relation with the localization of the vascular damage, high fibrinogen levels were observed either in CHD (p<0.00001) than in CVD (p<0.0008) but not in PVD (p=NS) in comparison with C. The lowest level of ATIII (p<0.04) and plasminogen (p<0.01) were revealed only in PVD, but not in CHD and CVD patients respect to C. Every patients with VD showed fibrinogen/plasminogen ratio significantly higher than C (CHD p<0.00001, CVD p<0.0001, PVD<0.002). These findings confirm again the fibrinogen role in vascular disease development, appearing more significative than the reduction of the fibrinolitic activity. However our data underline that the evaluation of the haemostatic/thrombotic balance (expressed as fibrinogen/plasminogen ratio) might be considered much more selective in VD patients rather than the separated evaluation of parameters studied also in relation with the localization of vascular damage.

Fibrinogen, plasminogen and antithrombin ED in dyslipidemic subjects with vascular disease

Saitta, A.;Imbalzano, E.;BONAIUTO, Michele
1996-01-01

Abstract

We studied, in dyslipidemic patients, the correlation between fibrinogen, plasminogen and antithrombin III (AT III) plasma levels and vascular disease (VD), to evaluate a more indicative aspects in relation not only with vascular damage but also with the localization of the vascular district involved. 273 dyslipidemic non diabetics subjects, of which 63 with VD and 174 without vascular complication were examined. Of 63 VD patients (mean age 54.4+13.0, 38 male and 25 female) 34 showed coronary heart disease (CHD), 21 cerebrovascular disease (CVD) and 8 peripheral vascular disease (PVD), the remaining 174 subjects (mean age 43.6±13.9, 95 male and 79 female) were studied as control (C). Fibrinogen (coagulative meth.) plasminogen and ATIII (immunolasernefelometric meth.) levels and fibrinogen/plasminogen ratio were performed. A fibrinogen increase correlated with age but not with sex was observed in all patients. VD subjects showed a significative rise of fibrinogen (p<0.00001) respect to C (398.2± 101.1 vs 328.5187.7 mg/dl) whereas there was no difference in plasminogen and ATIII levels between VD and C subjects. Fibrinogen/plasminogen ratio was significantly higher (p<0.00001) in VD than in C subjects (3.34±1.14 vs 2.66±0.78). In relation with the localization of the vascular damage, high fibrinogen levels were observed either in CHD (p<0.00001) than in CVD (p<0.0008) but not in PVD (p=NS) in comparison with C. The lowest level of ATIII (p<0.04) and plasminogen (p<0.01) were revealed only in PVD, but not in CHD and CVD patients respect to C. Every patients with VD showed fibrinogen/plasminogen ratio significantly higher than C (CHD p<0.00001, CVD p<0.0001, PVD<0.002). These findings confirm again the fibrinogen role in vascular disease development, appearing more significative than the reduction of the fibrinolitic activity. However our data underline that the evaluation of the haemostatic/thrombotic balance (expressed as fibrinogen/plasminogen ratio) might be considered much more selective in VD patients rather than the separated evaluation of parameters studied also in relation with the localization of vascular damage.
1996
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11570/2281624
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