Background Consistent evidence of benefit exists for radial access (RA) in ST-elevation acute myocardial infarction (STEMI). Patients with non ST-elevation acute coronary syndrome (NSTE-ACS) have a more varied ischemic and bleeding profile. No randomized trial of vascular access ever focused on NSTE-ACS and landmark studies did not provide conclusive results in this heterogeneous subset of patients. Methods We assessed in a meta-analysis whether RA is associated with improved outcomes in NSTE-ACS patients. Included studies had to meet the following criteria: 1) enrolling patients with NSTE-ACS undergoing invasive management; 2) reporting outcomes with respect to RA as compared with femoral access (FA); 3) reporting procedural, in-hospital 30-day, or long-term clinical outcomes. Studies were pooled with fixed and random effects models and heterogeneity was investigated by weighted meta-regression. Results Eleven studies were included encompassing 131.332 patients, 46.447 receiving RA and 84.885 receiving FA. Thirty-day mortality and MACE were lower with RA (p < 0.001 with fixed effects, p = NS with random effects model), but these results depended on one large observational database. Thirty-day major bleeding was consistently reduced by RA (p < 0.001), albeit an inverse relationship with the proportion of patients in each study receiving FA and experiencing major bleeding was evident. The association of RA with reduced long-term mortality was of borderline significance (p = 0.054 with random-effects, p = 0.001 with fixed-effect model) and also depended on major bleeding in FA patients. Conclusions RA is associated with better outcomes as compared with FA in NSTE-ACS, although this observation is influenced by nonrandomized comparisons. Large heterogeneity exists among studies. Registration This study is registered in the PROSPERO database (CRD42015029459).
Radial access in patients with acute coronary syndrome without persistent ST-segment elevation: Systematic review, collaborative meta-analysis, and meta-regression
ANDO', Giuseppe;ORETO, Giuseppe;
2016-01-01
Abstract
Background Consistent evidence of benefit exists for radial access (RA) in ST-elevation acute myocardial infarction (STEMI). Patients with non ST-elevation acute coronary syndrome (NSTE-ACS) have a more varied ischemic and bleeding profile. No randomized trial of vascular access ever focused on NSTE-ACS and landmark studies did not provide conclusive results in this heterogeneous subset of patients. Methods We assessed in a meta-analysis whether RA is associated with improved outcomes in NSTE-ACS patients. Included studies had to meet the following criteria: 1) enrolling patients with NSTE-ACS undergoing invasive management; 2) reporting outcomes with respect to RA as compared with femoral access (FA); 3) reporting procedural, in-hospital 30-day, or long-term clinical outcomes. Studies were pooled with fixed and random effects models and heterogeneity was investigated by weighted meta-regression. Results Eleven studies were included encompassing 131.332 patients, 46.447 receiving RA and 84.885 receiving FA. Thirty-day mortality and MACE were lower with RA (p < 0.001 with fixed effects, p = NS with random effects model), but these results depended on one large observational database. Thirty-day major bleeding was consistently reduced by RA (p < 0.001), albeit an inverse relationship with the proportion of patients in each study receiving FA and experiencing major bleeding was evident. The association of RA with reduced long-term mortality was of borderline significance (p = 0.054 with random-effects, p = 0.001 with fixed-effect model) and also depended on major bleeding in FA patients. Conclusions RA is associated with better outcomes as compared with FA in NSTE-ACS, although this observation is influenced by nonrandomized comparisons. Large heterogeneity exists among studies. Registration This study is registered in the PROSPERO database (CRD42015029459).Pubblicazioni consigliate
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