▪ Single-tablet regimens (STRs) have been associated to better adherence and virological control, longer persistence and reduced rates of hospitalizations compared to multi-tablet regimens (MTRs) in metaanalysis of randomized clinical trials[1,2] and previous observational reports [4-8] . However, most of these studies were conducted on antiretroviral (ARV) regimens which are no longer recommended. ▪ Moreover, a recent meta-analysis failed to demonstrate significant benefits of fixed dose combinations over individual drugs in terms of virological failure, drug resistance development and discontinuation for adverse events[9] . ▪ These findings, along with the current availability of both new and generic treatment options, prompts the need of an updated comparison of STRs versus MTRs as first-line antiretroviral therapy (ART).
Effectiveness of Single-vs Multiple-Tablet Regimens as First-line ART in ICONA Cohort
Nunnari G.;Pellicanò G. F.
2019-01-01
Abstract
▪ Single-tablet regimens (STRs) have been associated to better adherence and virological control, longer persistence and reduced rates of hospitalizations compared to multi-tablet regimens (MTRs) in metaanalysis of randomized clinical trials[1,2] and previous observational reports [4-8] . However, most of these studies were conducted on antiretroviral (ARV) regimens which are no longer recommended. ▪ Moreover, a recent meta-analysis failed to demonstrate significant benefits of fixed dose combinations over individual drugs in terms of virological failure, drug resistance development and discontinuation for adverse events[9] . ▪ These findings, along with the current availability of both new and generic treatment options, prompts the need of an updated comparison of STRs versus MTRs as first-line antiretroviral therapy (ART).Pubblicazioni consigliate
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