DTGisnowoneofthemostwidelyusedantiretroviraldrugsfortreatmentofbothART-naïveandexperiencedHIVpatientsduetoitshighefficacyandlowpotentialfordruginteractions[1-5]. Despitethehightolerabilitydemonstratedinclinicaltrials[1-3],recentobservationalstudieshaveraisedconcernsaboutDTGsafety,especiallywithregardtoneuropsychiatricadverseevents,withahigherincidencewhenDTGwasassociatedtoabacavir(ABC)[6-8]andinfrailsubgroups,aswomenandolderpatients[8].However,thesedatawasnotuniformlyconfirmedinreallifesettings[9,10]. TheaimofthisstudyistoestimatetheriskofvirologicalfailureanddiscontinuationofDTG-basedregimensintreatment-naïveandexperiencedHIVpatientsinalargeItaliancohort.

Effectiveness and discontinuation rate of dolutegravir (DGT)-based regimens as either first line or switch antiretroviral therapy (ART): data from the ICONA cohort.

G Nunnari;G. F. Pellicanò.
2017-01-01

Abstract

DTGisnowoneofthemostwidelyusedantiretroviraldrugsfortreatmentofbothART-naïveandexperiencedHIVpatientsduetoitshighefficacyandlowpotentialfordruginteractions[1-5]. Despitethehightolerabilitydemonstratedinclinicaltrials[1-3],recentobservationalstudieshaveraisedconcernsaboutDTGsafety,especiallywithregardtoneuropsychiatricadverseevents,withahigherincidencewhenDTGwasassociatedtoabacavir(ABC)[6-8]andinfrailsubgroups,aswomenandolderpatients[8].However,thesedatawasnotuniformlyconfirmedinreallifesettings[9,10]. TheaimofthisstudyistoestimatetheriskofvirologicalfailureanddiscontinuationofDTG-basedregimensintreatment-naïveandexperiencedHIVpatientsinalargeItaliancohort.
2017
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11570/3141678
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