DTGisnowoneofthemostwidelyusedantiretroviraldrugsfortreatmentofbothART-naïveandexperiencedHIVpatientsduetoitshighefficacyandlowpotentialfordruginteractions[1-5]. Despitethehightolerabilitydemonstratedinclinicaltrials[1-3],recentobservationalstudieshaveraisedconcernsaboutDTGsafety,especiallywithregardtoneuropsychiatricadverseevents,withahigherincidencewhenDTGwasassociatedtoabacavir(ABC)[6-8]andinfrailsubgroups,aswomenandolderpatients[8].However,thesedatawasnotuniformlyconfirmedinreallifesettings[9,10]. TheaimofthisstudyistoestimatetheriskofvirologicalfailureanddiscontinuationofDTG-basedregimensintreatment-naïveandexperiencedHIVpatientsinalargeItaliancohort.
Effectiveness and discontinuation rate of dolutegravir (DGT)-based regimens as either first line or switch antiretroviral therapy (ART): data from the ICONA cohort.
G Nunnari;G. F. Pellicanò.
2017-01-01
Abstract
DTGisnowoneofthemostwidelyusedantiretroviraldrugsfortreatmentofbothART-naïveandexperiencedHIVpatientsduetoitshighefficacyandlowpotentialfordruginteractions[1-5]. Despitethehightolerabilitydemonstratedinclinicaltrials[1-3],recentobservationalstudieshaveraisedconcernsaboutDTGsafety,especiallywithregardtoneuropsychiatricadverseevents,withahigherincidencewhenDTGwasassociatedtoabacavir(ABC)[6-8]andinfrailsubgroups,aswomenandolderpatients[8].However,thesedatawasnotuniformlyconfirmedinreallifesettings[9,10]. TheaimofthisstudyistoestimatetheriskofvirologicalfailureanddiscontinuationofDTG-basedregimensintreatment-naïveandexperiencedHIVpatientsinalargeItaliancohort.Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.