PURPOSE: The aim of our randomized clinical trial is to produce stronger evidence supporting barbed repositioning pharyngoplasty (BRP) as a therapeutic option for the treatment of obstructive sleep apnea (OSA). METHODS: The trial was a single-centre prospective controlled trial with two parallel arms (group A: BRP; group B: observation) and randomization. Baseline and 6 months polygraphy evaluating the apnea hypopnea index (AHI), oxygen desaturation index (ODI) and lowest oxygen saturation (LOS) were performed. To test the differences among groups the Student’s t-test. The role of each factor (univariate analysis) and their independent effect (multivariate analysis) was explored using logistic regression model as appropriate. Linear regression was also conducted. RESULTS: A significant reduction of AHI, ODI, LOS and Epworth Sleepiness Scale (ESS) values were recorded in the BRP group. BRP showed to be more effective than observation. Logistic regression showed that preoperative AHI is related significantly to postoperative AHI within the BRP group. A linear regression showed that higher baseline AHI predicts more significant postoperative absolute AHI reduction. CONCLUSIONS: BRP appears to be a promising technique and might be included within the surgical armamentarium of a sleep surgeon. Patients affected by severe OSA may benefit from this surgery with more significant reduction of AHI values.

Effectiveness of barbed repositioning pharyngoplasty or the treatment of obstructive sleep apnea (OSA)

CAMMAROTO, GIOVANNI
2019-10-30

Abstract

PURPOSE: The aim of our randomized clinical trial is to produce stronger evidence supporting barbed repositioning pharyngoplasty (BRP) as a therapeutic option for the treatment of obstructive sleep apnea (OSA). METHODS: The trial was a single-centre prospective controlled trial with two parallel arms (group A: BRP; group B: observation) and randomization. Baseline and 6 months polygraphy evaluating the apnea hypopnea index (AHI), oxygen desaturation index (ODI) and lowest oxygen saturation (LOS) were performed. To test the differences among groups the Student’s t-test. The role of each factor (univariate analysis) and their independent effect (multivariate analysis) was explored using logistic regression model as appropriate. Linear regression was also conducted. RESULTS: A significant reduction of AHI, ODI, LOS and Epworth Sleepiness Scale (ESS) values were recorded in the BRP group. BRP showed to be more effective than observation. Logistic regression showed that preoperative AHI is related significantly to postoperative AHI within the BRP group. A linear regression showed that higher baseline AHI predicts more significant postoperative absolute AHI reduction. CONCLUSIONS: BRP appears to be a promising technique and might be included within the surgical armamentarium of a sleep surgeon. Patients affected by severe OSA may benefit from this surgery with more significant reduction of AHI values.
30-ott-2019
File in questo prodotto:
File Dimensione Formato  
final phd thesis.pdf

accesso aperto

Descrizione: Tesi di Dottorato
Tipologia: Versione Editoriale (PDF)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 622.37 kB
Formato Adobe PDF
622.37 kB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11570/3146423
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact