Resistin is a mainly adipose-derived peptide hormone, that reduces insulin sensitivity in adipocytes, skeletal muscles and hepatocytes. Only in recent years resistin has been studied in liver disease and the regarding literature is very poor. According to recent studies considering resistin like a clinical biomarker in the assessment of liver cirrhosis, we propose an application of a finite mixture regression model with concomitant variable in order to individualize factors that influence resistin levels in patients affected by different virus hepatitis. The estimated model shows the existence of two separated components differing for the intercept and for some covariates; moreover high serum resistin levels do not seem to be associated with liver histological lesions by C virus, but only by B virus hepatitis.
A Mixture Regression Model for Resistin Levels Data
GARGANO, Romana;ALIBRANDI, Angela
2011-01-01
Abstract
Resistin is a mainly adipose-derived peptide hormone, that reduces insulin sensitivity in adipocytes, skeletal muscles and hepatocytes. Only in recent years resistin has been studied in liver disease and the regarding literature is very poor. According to recent studies considering resistin like a clinical biomarker in the assessment of liver cirrhosis, we propose an application of a finite mixture regression model with concomitant variable in order to individualize factors that influence resistin levels in patients affected by different virus hepatitis. The estimated model shows the existence of two separated components differing for the intercept and for some covariates; moreover high serum resistin levels do not seem to be associated with liver histological lesions by C virus, but only by B virus hepatitis.Pubblicazioni consigliate
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