Oxidant generation is part of the normal metabolism of many types of cells. To protect itself against exposure to noxious oxidants the lung has a well-developed antioxidant system. When an imbalance occurs between oxidants and antioxidants in favor of oxidants, oxidative stress is said to occur. Many experimental and clinical data suggest that an imbalance between oxidants and antioxidants (enzymatic and/or nonenzymatic) play a role in the pathogenesis of several respiratory disorders. Here we will review the nonenzymatic antioxidant systems of the lower airways. Most of the clinical data currently available refer to the glutathione system. Some studies have been recently performed on other nonenzymatic antioxidants such as vitamin C and vitamin A.

OXIDANTS AND ANTIOXIDANTS | Antioxidants, Nonenzymatic

CARAMORI, Gaetano
2006

Abstract

Oxidant generation is part of the normal metabolism of many types of cells. To protect itself against exposure to noxious oxidants the lung has a well-developed antioxidant system. When an imbalance occurs between oxidants and antioxidants in favor of oxidants, oxidative stress is said to occur. Many experimental and clinical data suggest that an imbalance between oxidants and antioxidants (enzymatic and/or nonenzymatic) play a role in the pathogenesis of several respiratory disorders. Here we will review the nonenzymatic antioxidant systems of the lower airways. Most of the clinical data currently available refer to the glutathione system. Some studies have been recently performed on other nonenzymatic antioxidants such as vitamin C and vitamin A.
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11570/3114115
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 1
  • ???jsp.display-item.citation.isi??? ND
social impact