In this chapter are illustrated the context and activities that have been pursued to develop a surface enhanced Raman spectroscopy technique for clinical applications in therapeutic drug monitoring with focus on anti-epileptic and anti-Parkinson drugs. We discuss how the surface nanostructure of sensors made of arrays of noble metal nanoparticle obtained by pulsed laser ablation in inert gas and in liquid affects their optical properties, in particular the wavelength, intensity and width of the surface plasmon. These in turn are shown to strongly influence the intensity and the spatial reproducibility of the enhanced Raman signals as functions of drug concentration. © Springer Nature Switzerland AG 2018.
Laser synthesized nanoparticles for therapeutic drug monitoring
Fazio E.;Santoro M.;Spadaro S.;Neri F.;
2018-01-01
Abstract
In this chapter are illustrated the context and activities that have been pursued to develop a surface enhanced Raman spectroscopy technique for clinical applications in therapeutic drug monitoring with focus on anti-epileptic and anti-Parkinson drugs. We discuss how the surface nanostructure of sensors made of arrays of noble metal nanoparticle obtained by pulsed laser ablation in inert gas and in liquid affects their optical properties, in particular the wavelength, intensity and width of the surface plasmon. These in turn are shown to strongly influence the intensity and the spatial reproducibility of the enhanced Raman signals as functions of drug concentration. © Springer Nature Switzerland AG 2018.Pubblicazioni consigliate
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