The purpose of this study is to characterize the structural changes of crystalline trehalose induced by a mild milling treatment. In particular, the structural changes induced by a gentle mechanical treatment, by mortar and pestle, are investigated as a function of time by means of two different spectroscopic techniques, namely x-ray diffractometry and IR spectroscopy. The obtained results clearly show that mild milling treatment induces a transformation from the original crystal phase, as a function of time, following a sigmoid trend. These results show how trehalose can be effectively used in many biotechnologic applications where it is fundamental to find an equilibrium point between stability and bioavailability.

X-ray and IR spectroscopy investigations on trehalose morphological modification effects induced by mild milling treatments

Castorina G.
Primo
;
Caccamo M. T.
Ultimo
2019

Abstract

The purpose of this study is to characterize the structural changes of crystalline trehalose induced by a mild milling treatment. In particular, the structural changes induced by a gentle mechanical treatment, by mortar and pestle, are investigated as a function of time by means of two different spectroscopic techniques, namely x-ray diffractometry and IR spectroscopy. The obtained results clearly show that mild milling treatment induces a transformation from the original crystal phase, as a function of time, following a sigmoid trend. These results show how trehalose can be effectively used in many biotechnologic applications where it is fundamental to find an equilibrium point between stability and bioavailability.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11570/3163947
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