Transcription factors (TFs) are a large family of regulatory proteins that can increase or decrease the transcription of a particular gene from deoxyribonucleic acid into the corresponding ribonucleic acid. The modular structure of TFs and the presence of distinct interacting domains determine the ability of these factors to associate with each other and with co-activating/repressing proteins. In addition, DNA polymorphisms or DNA methylation status cam alter TF-DNA binding and function. TFs control the expression of many inflammatory genes and they play a key role in the pathogenesis of a large number of human respiratory diseases contributing to determine disease severity and response to treatment.
Transcription Factors
Caramori G.;Nucera F.;Coppolino I.;Ruggeri P.;
2021-01-01
Abstract
Transcription factors (TFs) are a large family of regulatory proteins that can increase or decrease the transcription of a particular gene from deoxyribonucleic acid into the corresponding ribonucleic acid. The modular structure of TFs and the presence of distinct interacting domains determine the ability of these factors to associate with each other and with co-activating/repressing proteins. In addition, DNA polymorphisms or DNA methylation status cam alter TF-DNA binding and function. TFs control the expression of many inflammatory genes and they play a key role in the pathogenesis of a large number of human respiratory diseases contributing to determine disease severity and response to treatment.Pubblicazioni consigliate
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