SARS-CoV-2 compared with influenza and respiratory syncytial virus in terms of vertical transmission

With regard to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), influenza virus, and respiratory syncytial virus (RSV), the possibility of maternal-fetus transmission represents one of the most debated issues, with laboratory and clinical evidence often controversial. Also, when maternal-fetus transmission is assessed, scientific evidence considers this event as rare with several doubts about the perinatal outcomes, as other factors causing postpartum complications cannot be definitely excluded. Deep knowledge of the underlying mechanisms of SARS-CoV2, influenza virus, and RSV vertical transmission is crucial for planning the management of the affected mothers and monitoring and treating their infants. This chapter summarizes the current knowledge about the possibility and biological mechanisms underlying maternal-fetus transmission of SARS-CoV-2, influenza virus, and RSV