A large series of N-substituted-1,2,3,4-tetrahydroisoquinolines, bearing the most salient features described by our 3D pharmacophore model for this class of AMPAR antagonists, have been synthesized. When tested against audiogenic seizures in DBA/2 mice, some derivatives showed anticonvulsant properties. The most active compound was also tested in vitro using the patch clamp technique on hippocampal slices.

AMPA receptor antagonists: Synthesis and pharmacological evaluation

GITTO, Rosaria
Primo
;
DE LUCA, Laura;FERRO, Stefania;COSTA, LARA TANIA
Penultimo
;
CHIMIRRI, Alba
Ultimo
2007

Abstract

A large series of N-substituted-1,2,3,4-tetrahydroisoquinolines, bearing the most salient features described by our 3D pharmacophore model for this class of AMPAR antagonists, have been synthesized. When tested against audiogenic seizures in DBA/2 mice, some derivatives showed anticonvulsant properties. The most active compound was also tested in vitro using the patch clamp technique on hippocampal slices.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11570/1669988
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