La familiarità del carcinoma mammario. Osservazioni personali

Aim. The existence of hereditary mammary carcinoma has stimulated scientific interests and has allowed to identify BRCA1/BRCA2 involved in the heriditary transmission. The differentiation between sporadic and hereditary forms is fundamental for screening women, who have high risk of developing breast cancer. We observed 5 cases of patients in premenopausal staus with breast cancer, whose mothers in a period of 1 year to 16 months developed breast cancer. We report oue experience. Methods. Between 2001-2006, we observed 5 patients (32-51 years) in pre-menopausal age with breast cancer (4 in T1-N0-M0 stadium and 1 in T2-N0-M0 stadium). We also observed, in a period between 1 year and 16 months from the carcinoma diagnosis in the daughters, the development of breast carcinoma in the respective mothers (61-79 years), stadium T1-N0-M0. Results. We treated surgically all 10 patients. All are alive; in one of juvenile case we observed the appearance of a new secondary breast neoplasia (Lobular carcinoma). A patient in post menopausal age with bilateral cancer developed, at the moment, bone metastasis. Conclusions. Hereditary breast cancer is a controversial subject. There are no data about the development of breast cancer in the mothers of the patients with juvenile breast carcinoma. No topics exist concerning close screening programs in the mothers. The aim of our observation is purpose close follow-up for these patients (mothers), to identify, evaluate and study familiar breast cancers.