The aim of this paper is to analyze some specific challenges to foster innovation and creativity. We propose a conceptual framework based on two complementary perspectives: forms of innovation (closed vs open) and cultural approaches to enhance creativity. In literature, open innovation emerges is a model blurring organizational boundaries through ICT tools; it involves external actors in the process of knowledge creation. At the same time, culture can be considered as a prerequisite that promote or inhibit creativity. Research propositions that provide opportunities for examining a specific interaction between creativity, innovation and ICT tool for sharing knowledge are presented.