GENETIC MARKERS OF INDIVIDUAL SUSCEPTIBILITY AND OXIDATIVE STRESS IN SUBJECTS EXPOSED TO LOW DOSE OF BENZENE. PRELIMINARY DATA. In the present study we used AOPPs and AGE as early markers of oxidative stress in refinery oil workers. In addition we evaluated whether a genetically determined reduction in the ability to detoxify electrophilic compounds, such as that expected among individuals with glutathione S-transferase (GST) null genotypes might influence the levels of AOPPs thus increasing toxicity. The study was performed on 25 oil refinery workers and in 18 age-matched control subjects. We found a statistically significant increase of AOPPs in exposed workers with respect to controls while AGE levels were not different. Finally serum level of AOPPs and AGE were not correlated with the different GTS genotypes.
Indicatori genetici di suscettibilità individuale e stress ossidativo in soggetti a basse dosi di benzene. Dati Preliminari.
SPATARI, Giovanna;SAPIENZA, Daniela;SAITTA, SALVATORE;BARBARO, Mario
2011-01-01
Abstract
GENETIC MARKERS OF INDIVIDUAL SUSCEPTIBILITY AND OXIDATIVE STRESS IN SUBJECTS EXPOSED TO LOW DOSE OF BENZENE. PRELIMINARY DATA. In the present study we used AOPPs and AGE as early markers of oxidative stress in refinery oil workers. In addition we evaluated whether a genetically determined reduction in the ability to detoxify electrophilic compounds, such as that expected among individuals with glutathione S-transferase (GST) null genotypes might influence the levels of AOPPs thus increasing toxicity. The study was performed on 25 oil refinery workers and in 18 age-matched control subjects. We found a statistically significant increase of AOPPs in exposed workers with respect to controls while AGE levels were not different. Finally serum level of AOPPs and AGE were not correlated with the different GTS genotypes.Pubblicazioni consigliate
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