This presentation deals with a model of the dynamics of clonal expansion and immune competition of T cells [1] based on the approach of continuum mechanics. Field equations are mathematically constructed in the macroscopic framework of the thermodynamic theory of reacting fluid mixtures [2, 3], adapted to the case in which proliferative events occur [4, 5]. The introduced mathematical model is inspired by the experimental observation that during the treatment of type I hypersensitivity with the Specific ImmunoTherapy, the relative fraction of allergen specific Th1 cells increases [6] and its principal scope is to individuate key parameters and to evaluate their effect upon the domination of Th1 cell population over the Th2 one and viceversa.
A phenomenological approach to the dynamics of clonal expansion and immune competition of T cells
DOLFIN, Marina
2011-01-01
Abstract
This presentation deals with a model of the dynamics of clonal expansion and immune competition of T cells [1] based on the approach of continuum mechanics. Field equations are mathematically constructed in the macroscopic framework of the thermodynamic theory of reacting fluid mixtures [2, 3], adapted to the case in which proliferative events occur [4, 5]. The introduced mathematical model is inspired by the experimental observation that during the treatment of type I hypersensitivity with the Specific ImmunoTherapy, the relative fraction of allergen specific Th1 cells increases [6] and its principal scope is to individuate key parameters and to evaluate their effect upon the domination of Th1 cell population over the Th2 one and viceversa.Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
