Peripheral nerve sheet tumour (PNST) is the most common tumour in goldfish, observed with high prevalence in some colonies. The aim of this study was to investigate if goldfish PNST is so contagious as suspected and if it is a clonally transmissible cancer or not. Twelve PSNT-affected goldfish were enrolled in three different experiments (natural contact, artificial intimate contact, inoculation of tumour cell) but no tumour spread was observed in unaffected goldfish. In the fourth experiment comparative analysis of microsatellites between tumours and host tissues allowed to exclude a clonal origin of the tumour. A virus or a genetic involvement may explain the epidemiology of this tumour, which, in any case, represents a good model to increase the knowledge of neural tumours in animals and humans.
GOLDFISH PNST IS NOT CLONALLY TRANSMISSIBLE
MARINO, Gabriele;MACRI', Battesimo Consolato
2012-01-01
Abstract
Peripheral nerve sheet tumour (PNST) is the most common tumour in goldfish, observed with high prevalence in some colonies. The aim of this study was to investigate if goldfish PNST is so contagious as suspected and if it is a clonally transmissible cancer or not. Twelve PSNT-affected goldfish were enrolled in three different experiments (natural contact, artificial intimate contact, inoculation of tumour cell) but no tumour spread was observed in unaffected goldfish. In the fourth experiment comparative analysis of microsatellites between tumours and host tissues allowed to exclude a clonal origin of the tumour. A virus or a genetic involvement may explain the epidemiology of this tumour, which, in any case, represents a good model to increase the knowledge of neural tumours in animals and humans.Pubblicazioni consigliate
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