Background: It has been hypothesized that an increase in stiffness of great vessels is associated with reduced coronary blood flow. Animal studies are conflicting, and no human evidence, particularly by non invasive technique, has been provided. Objective: To assess the relationship beteween arterial wall stiffness measured by a non-invasive new tool „e-tracking, Aloka, Japan”, and basal coronary blood flow evaluated in the left anterior descending artery (LAD) by transthoracic doppler echocardiography. Methods: We studied 34 patients, mean age 52.8+/-15.1, 21 men, without history of coronary artery disease and with negative echo-stress. We used an Aloka (Japan) alfa-10 prosound echo-machine. LAD doppler velocities have been recorded at the distal segment of the vessel by phased array transducer. The following parameters have been evaluated: ratio between diastolic peak velocity (D) and systolic peak velocity (S), (D/S); ratio between velocity time integral of diastolic component (VTI-D) and velocity time integral of total flow (VTI-Tot), expressed as percentage (VTI-D/VTI-Tot %). Parameters of vascular stiffness have been evaluated by „e-tracking” with the same echo-machine, at the level of the common carotid artery just before bifurcation. The following parameters have been evaluated: Beta (stiffness parameter); AI (augmetation index); PWV (pulse wave velocity). The value of blood pressure (systolic and diastolic), evaluated in the left arm, have been included in the system for evaluation of these parameters. Results: Our results showed an inverse correlation between vascular stiffness parameters and coronary blood flow velocities (p<0.01), Table 1. Conclusion: Our data, obtained by non-invasive methods, show a negative correlation between vascular stiffness parameters and coronary blood flow velocities patterns. These preliminary data needs of further studies to be confirmed.

Relationship between coronary flow velocity and vascular stiffness

CARERJ, Scipione;ZITO, Concetta;DATTILO, GIUSEPPE;ORETO, Giuseppe;
2006-01-01

Abstract

Background: It has been hypothesized that an increase in stiffness of great vessels is associated with reduced coronary blood flow. Animal studies are conflicting, and no human evidence, particularly by non invasive technique, has been provided. Objective: To assess the relationship beteween arterial wall stiffness measured by a non-invasive new tool „e-tracking, Aloka, Japan”, and basal coronary blood flow evaluated in the left anterior descending artery (LAD) by transthoracic doppler echocardiography. Methods: We studied 34 patients, mean age 52.8+/-15.1, 21 men, without history of coronary artery disease and with negative echo-stress. We used an Aloka (Japan) alfa-10 prosound echo-machine. LAD doppler velocities have been recorded at the distal segment of the vessel by phased array transducer. The following parameters have been evaluated: ratio between diastolic peak velocity (D) and systolic peak velocity (S), (D/S); ratio between velocity time integral of diastolic component (VTI-D) and velocity time integral of total flow (VTI-Tot), expressed as percentage (VTI-D/VTI-Tot %). Parameters of vascular stiffness have been evaluated by „e-tracking” with the same echo-machine, at the level of the common carotid artery just before bifurcation. The following parameters have been evaluated: Beta (stiffness parameter); AI (augmetation index); PWV (pulse wave velocity). The value of blood pressure (systolic and diastolic), evaluated in the left arm, have been included in the system for evaluation of these parameters. Results: Our results showed an inverse correlation between vascular stiffness parameters and coronary blood flow velocities (p<0.01), Table 1. Conclusion: Our data, obtained by non-invasive methods, show a negative correlation between vascular stiffness parameters and coronary blood flow velocities patterns. These preliminary data needs of further studies to be confirmed.
2006
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11570/2325370
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact