The vascular endothelium plays a pivotal role in the response to dynamic forces due to the natural curvature and the acquired presence of focal atherosclerotic obstructions.Fluid shear stress induces a number of metabolic and structural responses in ECs that lead to the plaque formation.miR-21 and miR-21* are upregulated in flow-induced carotid lesions in Apoe-/- mice and also in human atherosclerotic plaques. However, in vivo data are scarce. Aim of this work is to study the in vivo miR-21 and -21* localization and their role in apoptosis in endothelial cells during atheroslerosis.
Role of miR-21 and -21* in endothelial cells during atherosclerosis
2013-01-01
Abstract
The vascular endothelium plays a pivotal role in the response to dynamic forces due to the natural curvature and the acquired presence of focal atherosclerotic obstructions.Fluid shear stress induces a number of metabolic and structural responses in ECs that lead to the plaque formation.miR-21 and miR-21* are upregulated in flow-induced carotid lesions in Apoe-/- mice and also in human atherosclerotic plaques. However, in vivo data are scarce. Aim of this work is to study the in vivo miR-21 and -21* localization and their role in apoptosis in endothelial cells during atheroslerosis.File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
