The vascular endothelium plays a pivotal role in the response to dynamic forces due to the natural curvature and the acquired presence of focal atherosclerotic obstructions.Fluid shear stress induces a number of metabolic and structural responses in ECs that lead to the plaque formation.miR-21 and miR-21* are upregulated in flow-induced carotid lesions in Apoe-/- mice and also in human atherosclerotic plaques. However, in vivo data are scarce. Aim of this work is to study the in vivo miR-21 and -21* localization and their role in apoptosis in endothelial cells during atheroslerosis.

Role of miR-21 and -21* in endothelial cells during atherosclerosis

2013

Abstract

The vascular endothelium plays a pivotal role in the response to dynamic forces due to the natural curvature and the acquired presence of focal atherosclerotic obstructions.Fluid shear stress induces a number of metabolic and structural responses in ECs that lead to the plaque formation.miR-21 and miR-21* are upregulated in flow-induced carotid lesions in Apoe-/- mice and also in human atherosclerotic plaques. However, in vivo data are scarce. Aim of this work is to study the in vivo miR-21 and -21* localization and their role in apoptosis in endothelial cells during atheroslerosis.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11570/2600176
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