The molecular recognition in water of neurotransmitter monoamine and trace amine hydrochlorides by p-tert-butylcalix[5]- arene 1 – bearing 4-sulphonatobutoxy groups at the lower rim – has been investigated. According to 1H NMR measurements, the hydrophobic cavity of receptor 1 best binds tyramine hydrochloride, Ka ¼ 5370 +/- 870 M–1.
Recognition in water of bioactive substrates by a sulfonato p-tert-butylcalix[5]arene
GATTUSO, Giuseppe;NOTTI, Anna;PARISI, Melchiorre;PISAGATTI, Ilenia
2014-01-01
Abstract
The molecular recognition in water of neurotransmitter monoamine and trace amine hydrochlorides by p-tert-butylcalix[5]- arene 1 – bearing 4-sulphonatobutoxy groups at the lower rim – has been investigated. According to 1H NMR measurements, the hydrophobic cavity of receptor 1 best binds tyramine hydrochloride, Ka ¼ 5370 +/- 870 M–1.File in questo prodotto:
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