The invention relates to the exploitation of low pressure conditions in the second analytical dimension of flow-modulated comprehensive two-dimensional gas chromatography (GCxGC) systems to reduce the requirements of high gas flows exiting the modulator. The invention specifically relates to flow modulators (3) characterized by the necessity of high gas flows (e.g.,>10 mL/min), to efficiently release effluent accumulated from the first column (12), onto the second column (20). The use of a second analytical column (20), with an internal diameter (ID) equal to, or exceeding 0.30 mm (e.g., 0.32 mm, 0.53 mm), along with vacuum outlet conditions, reduces the pressure conditions inside the second analytical column. Such intra-column low pressure conditions enables efficient release of effluent from the modulator, using lower gas flows (e.g., 7-8 mL/min).
A comprehensive gas chromatography system with flow modulation under vacuum conditions
MONDELLO, Luigi;TRANCHIDA, Peter Quinto;FRANCHINA, FLAVIO ANTONIO
2015-01-01
Abstract
The invention relates to the exploitation of low pressure conditions in the second analytical dimension of flow-modulated comprehensive two-dimensional gas chromatography (GCxGC) systems to reduce the requirements of high gas flows exiting the modulator. The invention specifically relates to flow modulators (3) characterized by the necessity of high gas flows (e.g.,>10 mL/min), to efficiently release effluent accumulated from the first column (12), onto the second column (20). The use of a second analytical column (20), with an internal diameter (ID) equal to, or exceeding 0.30 mm (e.g., 0.32 mm, 0.53 mm), along with vacuum outlet conditions, reduces the pressure conditions inside the second analytical column. Such intra-column low pressure conditions enables efficient release of effluent from the modulator, using lower gas flows (e.g., 7-8 mL/min).Pubblicazioni consigliate
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