P13.06: Does exogenous progesterone modify first trimester myocardial performance index (TEI) in euploid fetuses?

Objectives The aim of this study is to evaluate if exogenous progesterone may influence the myocardial performance (TEI) index in the first trimester. Methods Observational prospective study. All women referred to our centre for chorionic villous sampling (CVS) between March and August 2015 were included. All examinations were performed by the same investigator (F.P.) using a Samsung Medical System Accuvix A30 with a trans-abdominal probe. The examination included evaluation of crown–rump length (CRL), nuchal translucency (NT), and early morphologic study with echocardiography. Clinical and demographic information were recorded for each patient, including progesterone administration. Subsequently, a different investigator (L.D.) performed the trace analysis on the digitally stored images to evaluate right and left TEI Index. Outcome was assessed through results from CVS and phone enquiry. Patients were divided into 2 groups: treatment group (P GROUP) receiving exogenous progesterone (a standard dose for at least 1 week) and controls (C GROUP). Only single viable fetuses with CRL between 42 and 85 mm were included in the analysis. We excluded cases with NT > 3.5 mm, unsatisfactory quality of ultrasound, cardiac and extracardiac malformations, chromosomal aberrations identified during pregnancy or after birth. Results A total of 226 women were analysed (99 P GROUP, 127 C GROUP). No difference in left (P GROUP 0.42 ± 0.10, C GROUP 0.41 ± 0.10, p 0.39) and right (P GROUP 0.33 ± 0.11, C GROUP 0.33 ± 0.12, p 0.77) TEI index between the two groups were found, even when we stratified by gestational age. Conclusions Fetuses exposed to exogenous progesterone do not show changes in myocardial performance parameters in the first trimester.