CEUS is a valid diagnostic tool for study several districts. There are numerous pathological conditions of the eye in which CEUS can be very helpful or detrimental. Objective: To determine the feasibility of using quantitative contrast-enhanced ultrasonography (CEUS) to detect uveal perfusional changes in uveal tumors in cats. In this prospective study, 9 healthy cats (18 eyes) and 6 pathologic cats (8 eyes) affected by primary and secondary uveal tumors (melanoma and lymphoma) were examined. In all animals an ophthalmic and ultrasonographic examination of the eye was performed. A standard grey-scale scan was performed, followed by the CEUS examination. After subjective evaluation of the videos, 3 region of interest (ROI) were drawn for each eye at the iris (I), ciliary bodies (CB) and choroid (C). Time-intensity curves were generated using commercial software (Qcontrast, Bracco) and perfusion parameters were automatically calculated. Peak intensity (PI) and time to peak (TTP) were statistically compared. In the normal group, PI of the iris was significantly lower when compared to ciliary bodies and choroid. (31.18% versus 39.10 e 58.50%; P<0.05), with TTP values between 20 (I, CB) and 15 seconds (C). In the pathologic group, the PI values of the anterior neoplastic uvea were not significantly different when compared to choroid, not affected by the disease process (42.94% versus 46.1 e 64.49%, P>0.05). PI of the neoplastic group was increased when compared to controls, but not significantly. Contrast-enhanced ultrasonography can detect uveal perfusion changes in primary or secondary tumor of the anterior uvea, but it was not possible to identify cutt of values that differentiate the normal uvea from neoplastic.

CONTRAST-ENHANCED ULTRASONOGRAPHY IN NORMAL AND NEOPLASTIC UVEA IN CATS

QUARTA, MICHELA;PUGLIESE, Michela;
2015-01-01

Abstract

CEUS is a valid diagnostic tool for study several districts. There are numerous pathological conditions of the eye in which CEUS can be very helpful or detrimental. Objective: To determine the feasibility of using quantitative contrast-enhanced ultrasonography (CEUS) to detect uveal perfusional changes in uveal tumors in cats. In this prospective study, 9 healthy cats (18 eyes) and 6 pathologic cats (8 eyes) affected by primary and secondary uveal tumors (melanoma and lymphoma) were examined. In all animals an ophthalmic and ultrasonographic examination of the eye was performed. A standard grey-scale scan was performed, followed by the CEUS examination. After subjective evaluation of the videos, 3 region of interest (ROI) were drawn for each eye at the iris (I), ciliary bodies (CB) and choroid (C). Time-intensity curves were generated using commercial software (Qcontrast, Bracco) and perfusion parameters were automatically calculated. Peak intensity (PI) and time to peak (TTP) were statistically compared. In the normal group, PI of the iris was significantly lower when compared to ciliary bodies and choroid. (31.18% versus 39.10 e 58.50%; P<0.05), with TTP values between 20 (I, CB) and 15 seconds (C). In the pathologic group, the PI values of the anterior neoplastic uvea were not significantly different when compared to choroid, not affected by the disease process (42.94% versus 46.1 e 64.49%, P>0.05). PI of the neoplastic group was increased when compared to controls, but not significantly. Contrast-enhanced ultrasonography can detect uveal perfusion changes in primary or secondary tumor of the anterior uvea, but it was not possible to identify cutt of values that differentiate the normal uvea from neoplastic.
2015
978-88-909002-0-7
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11570/3094733
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