Behavioural and Psichological Syntoms in Alzheimer’s disease. The burden on caregiver

The care burden with patients with Alzheimer's disease is largely put on their families. The relative caregivers are under a great deal of stress, and consequently, they often show depression, insomnia, antisocial behavior and a general worsening in the qualitive of life (Ryu et al.2011). the present study evaluated which behavioral disturbances are the major cause of stress for caregivers of patients with Alzheimer's disease. Patients and caregivers: we enrolled 126 patients (61% F, 39% M; mean age 73,9 years, SD=6.51; mean M.M.S.E:15,97 SD=5,46 consecutively admitted to the Alzheimer Special Care Unit of Neurosciences at the University of Messina. Inclusion criteria were age>50 years, diagnosis of probable AD AD according to the NINCS-ADRDA criteria (McKhann, G., et al. 1984). Exclusion criteria were: previous stroke and/or brain trauma, co-morbidity with other neurological or psychiatric diseases, co-existence of severe internal diseases, history of alcohol and or drug abuse. One caregiver for patient partecipated in the study (73%F,27%M; mean age 55.73 years). Methods All patients underwent an extensive anamnestic, neuroradiological, neurological and neuropsychological evaluation. We also investigated activities of daily living (with ADL and IADL scales) as well as cognitive level (with MMSE). The behavioural and psychological symptoms of dementia (BPSD) were assessed with the Neuropsychiatric Inventory (NPI, Cummings et al., 1994). An in-depth interview was carried out with the caregiver that included the administration of various scales and questionnaires; in particular, the impact of stress was assessed with the Caregiver Burden Inventory (CBI; Novak and Guest, 1989). A multiple regression analysis was carried out with the various neuropsychiatric symptoms on the NPI as independent variables and the distress of the caregiver on the CBI test as dependent variable. Results and comments The distress of the caregivers correlated with all NPI scales except apathy. The multiple regression model showed that the most predictive patients’ symptoms were the presence of agitation, depression/dysphoria, irritability and eating disorders. Overall, the model explained 64% of the total variance. The results confirmed a very close relationship between severity of BPSD and distress of caregivers and indicated the most critical factors mediating this relationship. The behavioural and psychological symptoms of the patient affect the caregiver’s well-being as much (or more) than the cognitive deficits. Caregiver support and the treatment of behavioural disturbances in AD patients represents one key area of intervention in the care for patients with dementia. • Ryu, S.H., Ha, J.H., Park, D.H., Yu, J., and Livingston, G. (2011). Persistence of neuropsychiatric symptoms over six months in mild cognitive impairment in community-dwelling Korean elderly. International Journal of Psychogeriatry, 23: 214–220. • Mitrani, V.B, and Czaja, S.J. (2000). Family-based therapy for dementia caregivers: Clinical observations. Aging and Mental Health, 4: 200-209. • Novak, M., and Guest, C. (1989). Application of a multidimensional caregiver burden inventory. The Gerontologist, 29: 798-803.