Serotonin (5-HT) is a biogenic amine which induces metabolic effects in different cell types, including leukocytes. A significant effect of trekking exercise on horse 5-HT plasma levels was observed. Immune cells uptake 5-HT because they express 5-HT receptors and intracellular 5-HT transporter (SERT). On this basis, aim of this study was to investigate the effect of hippodrome intensive training on plasma 5-HT levels, SERT, 5-HT2A and 5-HT1B receptor expression. Trotter horses (n.5), aged 6+/-3 years, were trained on track. Compared to pre-exercise values, 5-HT showed significant higher levels. A negative influence of exercise on SERT and 5-HT1B and a positive on 5-HT2A expression may be related to a lower degree of 5-HT storage and consequently to a higher plasma 5-HT levels.
Physical exercise affects serotoninergic metabolism in horse leukocytes
FERLAZZO, Alida;D'ASCOLA, ANGELA;BRUSCHETTA, Giuseppe;GIUNTA, RENATO PAOLO;ZANGHI', GABRIELLA
2016-01-01
Abstract
Serotonin (5-HT) is a biogenic amine which induces metabolic effects in different cell types, including leukocytes. A significant effect of trekking exercise on horse 5-HT plasma levels was observed. Immune cells uptake 5-HT because they express 5-HT receptors and intracellular 5-HT transporter (SERT). On this basis, aim of this study was to investigate the effect of hippodrome intensive training on plasma 5-HT levels, SERT, 5-HT2A and 5-HT1B receptor expression. Trotter horses (n.5), aged 6+/-3 years, were trained on track. Compared to pre-exercise values, 5-HT showed significant higher levels. A negative influence of exercise on SERT and 5-HT1B and a positive on 5-HT2A expression may be related to a lower degree of 5-HT storage and consequently to a higher plasma 5-HT levels.Pubblicazioni consigliate
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