Effects of a new vaginal cream containing visnadine, prenylflavonoids and bovine colostrum on Vaginal Health Index Score and Female Sexual Function Index in post-menopausal sexually active women affected by vaginal dryness: A pilot study

Objective: To evaluate the effects of a new vaginal cream containing visnadine (0.30%), prenylflavonoids (0.10%) and bovine colostrum (1%) on Vaginal Health Index Score (VHIS) and Female Sexual Function Index (FSFI) in post-menopausal sexually active women affected by vaginal dryness. Patients and methods: We performed a prospective pilot study, enrolling 15 post-menopausal sexually active women affected by vaginal dryness. The mean age of participants was 56.8 ± 4.6 years with parity mean 1.6 ± 1. All women gave consent and underwent VHIS evaluation and FSFI test. Following baseline evaluation, women underwent 15 days of vaginal treatment with one application per day of the new vaginal cream. Following treatment, women were evaluated again using the same methods of the pre-treatment phase. Results: Following treatment there was significant improvement in elasticity (p = 0.03), fluid secretion type and consistency (p = 0.01), pH (p = 0.03), epithelization of vaginal mucosa (p = 0.04), moisture (p = 0.04) and total VHIS (p = 0.0001). Similarly, after the treatment there was also a significant improvement of lubrication (p = 0.01), orgasm (p = 0.01), satisfaction (p = 0.02), pain (p = 0.03) and total FSFI score (p = 0.004). No significant differences regarding desire (p = 0.57) and arousal (p = 0.61) were found. None of the women reported any local or systemic side effect during the treatment. Conclusion: We demonstrated a significant improvement of both VHIS and FSFI score in post-menopausal sexually active women after a treatment with vaginal cream containing visnadine, prenylflavonoids and bovine colostrum. Given that our results are based on a pilot study, we postulate that the treatment with this new vaginal cream may significantly reduce vaginal dryness in post-menopausal women and improve their sexual wellbeing.