My research work, during the Ph.D. course, has been focused mainly on the use different mass spectrometry techniques for the analysis of complex sample. Much of the experimentation has been performed in the field of gas chromatography, even though liquid chromatography has also been exploited. The techniques used have been: single quadrupole mass spectrometry tandem with comprehensive gas chromatography (GC×GC-MS), single quadrupole mass spectrometry tandem with fast comprehensive gas chromatography, and quadrupole time of flight tandem with ion mobility (IM-Q-ToF). The use of such powerful analytical instrumentation, enabled the attainment of detailed information of sample, and in particular related to food safety. Comprehensive 2D GC is a relatively new technique, developed in 1991 and can be considered, without a doubt, at the same level of the OTC, in terms of the revolutionary impact that it has had on the GC field. With regards to loop-type cryogenic modulation, I have been involved in food-sample applications (mussels, claim and fish) and in the optimization and development studies. In the latter case the use of micro bore columns in both dimensions is emphasized. Regarding the ion mobility Q-ToF I was involved in the separation of isomers in different type of milk and in the calculation of collision cross section value improve lipid identification.
|Titolo:||Use of advanced mass spectrometry technologies for the analysis of high complex samples|
|Data di pubblicazione:||12-dic-2017|
|Appare nelle tipologie:||Tesi di dottorato|