14.g Altra Tipologia

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Advanced liquid chromatography techniques and quantitative structure-retention relationship approach for phenolic compounds analysis: a journey toward greener and reliable analytical methods

In the -omics field, phenolic compounds remain analytically demanding for liquid chromatography (LC) due to their abundance, structural heterogeneity, and isomerism. While advances in HPLC, miniaturised formats (nano-/capillary-/micro-LC) and comprehensive two-dimensional LC (LC×LC), coupled with PDA and MS (or MS/MS and HRMS) detection, have broadened capabilities, routine workflows still have to deal with identification uncertainty and solvent-intensive method optimisation. This t...

QUALITÀ E SICUREZZA DI MATRICI ALIMENTARI CON PROPRIETÀ SALUTISTICHE

Food safety and quality are two fundamental pillars for protecting consumer health. Furthermore, the consumption of functional foods brings specific health benefits, improving well-being or reducing the risk of disease. These foods are promoted through nutritional and health claims, communication tools regulated by European Union. However, their use requires rigorous scientific and regulatory control to avoid misleading practices. This thesis provides an overview of the chemical quality and ...

Genetic Variability and Drug Resistance of Hepatitis B Virus in Treatment-Naïve Chronic Hepatitis B Patients

Despite the availability of an effective vaccine and antiviral therapies designed to suppress viral replication by targeting the catalytic region of the RT gene, HBV infection remains a significant public health challenge worldwide. This study aimed to examine the variability of the HBV whole genome in HBsAg-positive individuals who had never received specific antiviral treatments with NAs. The goal was to investigate the prevalence of viral quasispecies among these patients, focusing on thos...

MODULATION OF THE WNT/BETA-CATENIN PATHWAY IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION (BETA-MI STUDY)

Background: Cardiac fibrosis is central to post-infarction remodeling and heart failure development. The Wnt/β-catenin pathway is involved in fibrosis and myocardial repair, but its clinical significance remains unclear. This study aims to investigates β-catenin and its inhibitor DKK1 after a myocardial infarction and explores their modulation by P2Y12 inhibitors. Methods: A single-center observational cohort study included 50 patients undergoing PCI: 40 with STEMI and 10 with CCS. β-catenin...

EVALUATION OF POSSIBLE ANTI-INFLAMMATORY AND NEUROPROTECTIVE EFFECTS OF CHLOROGENIC ACID: AN INNOVATIVE APPROACH FOR THE MANAGEMENT OF NEUROINFLAMMATION

Neuroinflammation and the kynurenine-immune pathway are known to play a key role in inflammation-induced psychiatric disorders. There is evidence in the literature on the anti-inflammatory and antioxidant properties of naturally occurring polyphenols. The SHSY5Y (human neuroblastoma cells) and HMC3 (human microglia) cell lines are used to reproduce an in vitro model of neuroinflammation. The evaluation of the expression profile of inflammatory molecules (IL6, IL 1 beta and TNF alpha) was perf...

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