Liver enzyme elevations (LEE) are common in course o f Human Immunodeficiency Virus (HIV) infection and have been historically linked to Hepatitis B (HBV) or C (HCV) co-infection. § LEE have often a multifactorial etiopathogenesis, and the possibility of drug toxicity should always be investigated in patients developing LEE. § LEE that develops soon after combined antiretroviral therapy (cART) initiation in patients co-infected with HBV or HCV can also be driven by the immune recovery that occurs in the first weeks after starting cART, when a fast CD4+T-lymphocyte rise and a rapid HIV-RNA decline can cause an immune reconstitution syndrome (IRIS). § Although LEE are now less frequently observed than in the past, few data are available on new drug classes such as integrase strand transfer inhibitors (INSTI), especially in the clinical post-marketing phase.

Liver enzyme elevations according to the first line cART regimen: real life data from th ICONA cohort.

G. Nunnari;G. F. Pellicanò.
2018-01-01

Abstract

Liver enzyme elevations (LEE) are common in course o f Human Immunodeficiency Virus (HIV) infection and have been historically linked to Hepatitis B (HBV) or C (HCV) co-infection. § LEE have often a multifactorial etiopathogenesis, and the possibility of drug toxicity should always be investigated in patients developing LEE. § LEE that develops soon after combined antiretroviral therapy (cART) initiation in patients co-infected with HBV or HCV can also be driven by the immune recovery that occurs in the first weeks after starting cART, when a fast CD4+T-lymphocyte rise and a rapid HIV-RNA decline can cause an immune reconstitution syndrome (IRIS). § Although LEE are now less frequently observed than in the past, few data are available on new drug classes such as integrase strand transfer inhibitors (INSTI), especially in the clinical post-marketing phase.
2018
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11570/3141681
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