Incidence of dyslipidemia and modification of atherosclerotic cardiovascular disease (ASCVD) risk in HIV-infected patients who switch away from tenofovir disoproxil fumarato (TDF)-based to TDF-sparing regimens in the ICONA Foundation Cohort

Increasing values of total cholesterol (TC), high-density lipoproteins (HDL), low-density lipoproteins (LDL) and triglycerides (TG) were observed among HIV patients on combination ART (cART) switching away from TDF–based regimens in randomised trials. However, the impact of these changes in terms of modification of ASCVD risk or need for lipid-lowering therapy has not been assessed. This study aimed to characterise changes in lipid profile and ASCVD risk after switching away from a TDF-based to a TDF-sparing cART in a real-world setting.