Both EFV and DTG have been associated with a higher risk of neuropsychiatric adverse events (NPAEs) compared to other antiretrovirals. Despite this, comparison of NPAEs risk between this two drugs in observational cohorts are lacking. The aim of the study was to compare the risk of neuropsychiatric toxicity among DTG-based, EFV-based regimens as well as other currently recommended first-line ART over a period in which all these treatment strategies have been used.
Comparative neuropsychiatric toxicity profile of dolutegravir (DGT)-based versus efavirenz (EFV)-based versus other recommend first-line antiretroviral therapies (ART): data from ICONA Foundation Study Cohort.
G. NunnariMembro del Collaboration Group
;G. F. PellicanòMembro del Collaboration Group
2019-01-01
Abstract
Both EFV and DTG have been associated with a higher risk of neuropsychiatric adverse events (NPAEs) compared to other antiretrovirals. Despite this, comparison of NPAEs risk between this two drugs in observational cohorts are lacking. The aim of the study was to compare the risk of neuropsychiatric toxicity among DTG-based, EFV-based regimens as well as other currently recommended first-line ART over a period in which all these treatment strategies have been used.File in questo prodotto:
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