Serious liver events and liver-related deaths in HIV/HCV co.infected patients with diabetes: data from the ICONA Foundation Cohort Study.

Combination antiretroviral therapy has significantly reduced the mortality and morbidity among HIV-infected patients. The improvement in AIDS-related survival rates resulted in an increase of non-HIV-related deaths, including liver-related deaths. HCV infection seems to be associated with an increased incidence rate of diabetes, which itself plays a major role in the acceleration of liver disease and in the increased probability of liver-related complications. The aim of our study was firstly, to investigate the association between HCV infection and diabetes, and, secondly, to determine the risk factors of serious liver events (SLE) and liver-related deaths (LRD) and fibrosis progression among HIV/HCV co-infected patients.