Although several randomized studies have shown that PI/r-including first-line regimens have lower efficacy as compared to those including integrase inhibitors, they are still used in a number of conditions, mainly due to their high genetic barrier. We aimed to reproduce in a real-life setting results of the ACTG 5257 trial, comparing virologic response, durability and tolerability of first line raltegravir (RAL)-including regimens to regimens including either darunavir/ritonavir (DRV/r) or atazanavir/r (ATV/r).
Durability and tolerability of first-line combination including two NRTI and RAL or ATV/r or DRV/r in patients enrolled in the ICONA Foundation cohort
G. NunnariMembro del Collaboration Group
;G. F. PellicanòMembro del Collaboration Group
2016-01-01
Abstract
Although several randomized studies have shown that PI/r-including first-line regimens have lower efficacy as compared to those including integrase inhibitors, they are still used in a number of conditions, mainly due to their high genetic barrier. We aimed to reproduce in a real-life setting results of the ACTG 5257 trial, comparing virologic response, durability and tolerability of first line raltegravir (RAL)-including regimens to regimens including either darunavir/ritonavir (DRV/r) or atazanavir/r (ATV/r).File in questo prodotto:
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