Reducing pill burden is more durable than reducing drug burden as strategy of HIV treatment simplification.

Reducing antiretroviral toxicity and improving adherence involves different switching strategies as reducing pill burden by single-tablet regimen (STR) or drug burden by regimens with two orone drug (less drug regimen, LDR). We aimed to compare the two approaches in patients who switched with suppressed viremia. Materials and methods: From the Italian ICONA cohort, patients with undetectable HIV RNA switching to STR or LDR from any triple regimen were selected. Drug discontinuation by any cause (DAC) was the end-point of the analysis assessed by incidence rates and Poisson regression.