Switching to a TAF-based or to TDF-sparing (dual combination, DC) regimens is considered as safer than continuing to take TDF-containing regimens, particularly for bone/kidney health. The main aim of this analysis was to evaluate the possible impact of recent results from randomised studies, which led to a change in treatment guidelines, on the observed rate of switch from TDF to TAF-based regimens or TDF-sparing DC in real-life and to identify the determinants of switch separately for the two strategies, with focus on current eGFR values.
Determinants of switching to TAF-based cART or dual combinations (DC) from TDF-based regimens in a cohort of HIV-infected individuals with controlled viral load <50 copies/mL.
G. Nunnari;G. F. Pellicanò.
2019-01-01
Abstract
Switching to a TAF-based or to TDF-sparing (dual combination, DC) regimens is considered as safer than continuing to take TDF-containing regimens, particularly for bone/kidney health. The main aim of this analysis was to evaluate the possible impact of recent results from randomised studies, which led to a change in treatment guidelines, on the observed rate of switch from TDF to TAF-based regimens or TDF-sparing DC in real-life and to identify the determinants of switch separately for the two strategies, with focus on current eGFR values.File in questo prodotto:
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