▪Despite the universal access to healthcare services, advanced HIV presentation (HIVinfected subjects presenting for care with CD4 count <200 cell/mL or with an AIDSdefining event [ADE])[1] and, particularly, AIDS presentation are still an issue, even in high-income countries. ▪ Advanced HIV presentation has been associated with poor clinical and virologic outcomes including: higher risk of mortality, particularly over the first year of diagnosis, even with a prompt ART initiation [2,3], reduced chance of viral suppression[4], increased risk of hospitalization and cost of care [5,6] and challenges in ART choice due to the higher risk for ART intolerance/toxicity and the more potential for drug-drug interactions. ▪ Limited data on ART strategies, treatment responses and survival in this vulnerable population in more recent years, after the availability of more effective and tolerable antiretroviral drugs, are available.

Persistent poor clinical outcomes for AIDS presentation in Italy over the last decade

G. Nunnari;G. F. Pellicanò.
2020

Abstract

▪Despite the universal access to healthcare services, advanced HIV presentation (HIVinfected subjects presenting for care with CD4 count <200 cell/mL or with an AIDSdefining event [ADE])[1] and, particularly, AIDS presentation are still an issue, even in high-income countries. ▪ Advanced HIV presentation has been associated with poor clinical and virologic outcomes including: higher risk of mortality, particularly over the first year of diagnosis, even with a prompt ART initiation [2,3], reduced chance of viral suppression[4], increased risk of hospitalization and cost of care [5,6] and challenges in ART choice due to the higher risk for ART intolerance/toxicity and the more potential for drug-drug interactions. ▪ Limited data on ART strategies, treatment responses and survival in this vulnerable population in more recent years, after the availability of more effective and tolerable antiretroviral drugs, are available.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11570/3151807
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