2DR with DTG+3TC resulted effective as maintenance therapy in RCT (Tango, Aspire), in pts with no prior VF and no documented NRTI or INSTI resistance Ø The high virological efficacy of DTG+3TC has been extensively showed also in unselected real-life cohorts1 Ø Real-life data showed also that up to 40% of all 2DR prescriptions are in pts with prior VF, 14% of DTG+3TC 2 Ø Few data about the use of DTG+3TC in the context of previous VF are available: o Dolulam study: pilot study, 27 HTE pts with tolerability issues, 67% of pts at least 1 RAM, 52% at least resistant to one drug 3 o ART-PRO pilot study: 21 pts with historical resistance to 3TC, no VF at 48w4
Effect of past virological failure on Dolutegravir+Lamivudine as maintenance regimen
G. Nunnari;G. F. Pellicanò.
2020-01-01
Abstract
2DR with DTG+3TC resulted effective as maintenance therapy in RCT (Tango, Aspire), in pts with no prior VF and no documented NRTI or INSTI resistance Ø The high virological efficacy of DTG+3TC has been extensively showed also in unselected real-life cohorts1 Ø Real-life data showed also that up to 40% of all 2DR prescriptions are in pts with prior VF, 14% of DTG+3TC 2 Ø Few data about the use of DTG+3TC in the context of previous VF are available: o Dolulam study: pilot study, 27 HTE pts with tolerability issues, 67% of pts at least 1 RAM, 52% at least resistant to one drug 3 o ART-PRO pilot study: 21 pts with historical resistance to 3TC, no VF at 48w4Pubblicazioni consigliate
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