In the continuous attempt to reach high performing therapeutic tools, the attention was focused on the development of multimodal nanodevices combining the properties of therapeutic agents with the detectability of contrast ones, providing all-in-one nanomedicine tools. In the present work, we discuss the synthesis, the characterization, and the biological profile of a new fluorescent hybrid nanodevice based on the combination of cationic cyclodextrin and graphene (GCD@Ada-Rhod, see Figure 1). Additionally, the performance of GCD@Ada-Rhod as miRNA nanocarrier and its ability to modify the expression of cancer-correlated genes were investigated. [1-2]

Multifunctional fluorescent Graphene-Cyclodextrin nanoplatforms

Giulia Neri
Primo
;
Angela Scala;Antonino Mazzaglia;Anna Piperno
Ultimo
2021-01-01

Abstract

In the continuous attempt to reach high performing therapeutic tools, the attention was focused on the development of multimodal nanodevices combining the properties of therapeutic agents with the detectability of contrast ones, providing all-in-one nanomedicine tools. In the present work, we discuss the synthesis, the characterization, and the biological profile of a new fluorescent hybrid nanodevice based on the combination of cationic cyclodextrin and graphene (GCD@Ada-Rhod, see Figure 1). Additionally, the performance of GCD@Ada-Rhod as miRNA nanocarrier and its ability to modify the expression of cancer-correlated genes were investigated. [1-2]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11570/3209305
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