Monte Carlo (MC) simulation of radiation emitted by radio-pharmaceuticals and its interaction with living matter is the most accurate and patient-specific technique for internal dosimetry in nuclear medicine. Taking morphological information from CT scans to build 3D digital phantoms and functional information from PET or SPECT scans to model 3D radionuclide distributions, we developed voxel-level MC simulations by means of GATE and GAMOS, user friendly GEANT4-based codes. The dosimetric results obtained by the two codes for some diagnostic (e.g. 18F-choline PET/CT) and therapeutic (e.g. 90Y TARE therapy of HepatoCellular Carcinoma) cases will be presented and compared.
Internal dosimetry in diagnostic and therapeutic nuclear medicine using GATE and GAMOS Monte Carlo simulations
Daniele Pistone
;Antonio Stefano Italiano;Lucrezia Auditore;Ernesto Amato
2020-01-01
Abstract
Monte Carlo (MC) simulation of radiation emitted by radio-pharmaceuticals and its interaction with living matter is the most accurate and patient-specific technique for internal dosimetry in nuclear medicine. Taking morphological information from CT scans to build 3D digital phantoms and functional information from PET or SPECT scans to model 3D radionuclide distributions, we developed voxel-level MC simulations by means of GATE and GAMOS, user friendly GEANT4-based codes. The dosimetric results obtained by the two codes for some diagnostic (e.g. 18F-choline PET/CT) and therapeutic (e.g. 90Y TARE therapy of HepatoCellular Carcinoma) cases will be presented and compared.Pubblicazioni consigliate
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