Oxygen sensing is the fundamental process through which organisms respond to changes in oxygen levels. Complex networks exist allowing the maintenance of oxygen levels through the perception, capture, binding, transport and delivery of molecular oxygen. The brain extreme sensitivity to oxygen balance makes the dysregulation of related processes crucial players in the pathogenesis of neurodegenerative diseases. Here we wish to review the most relevant advances in oxygen sensing in relation to Alzheimer's Disease, Parkinson's Disease and Amyotrophic Lateral Sclerosis.
Oxygen sensing in neurodegenerative diseases: current mechanisms, implication of transcriptional response and pharmacological modulation
Casili, Giovanna;Cuzzocrea, Salvatore;Esposito, Emanuela;Paterniti, Irene;
2022-01-01
Abstract
Oxygen sensing is the fundamental process through which organisms respond to changes in oxygen levels. Complex networks exist allowing the maintenance of oxygen levels through the perception, capture, binding, transport and delivery of molecular oxygen. The brain extreme sensitivity to oxygen balance makes the dysregulation of related processes crucial players in the pathogenesis of neurodegenerative diseases. Here we wish to review the most relevant advances in oxygen sensing in relation to Alzheimer's Disease, Parkinson's Disease and Amyotrophic Lateral Sclerosis.File in questo prodotto:
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