The development of nanostructured assemblies based on amphiphilic beta-cyclodextrins (aCD) is a crucial step for the fabrication of technological devices with great potential in the diagnosis of various diseases and in delivery of bioactive compounds for therapeutic applications. The synergy between the chemical functionalization of aCD and their typical self-assembly behavior and drug binding abilities has been fruitfully employed, during our ten-years scientific runway, for the development of potential diagnostic tools, sensors and drug delivery systems. Specifically, nanoassemblies based on properly functionalized aCD have been proposed for efficient delivery of anticancer drugs and/or phototherapeutics.[1-4] More recently, the great potential of hybrid aCD nanoassemblies bearing plasmonic or magnetic features has been exploited for controlled release of dopamine [5] and for selective amyloid beta recognition and fishing,[6] respectively. An overview of our most relevant aCD-based supramolecular systems will be presented pointing out that a proper combination of chemical functionalization, nanoassembly decoration and host guest interactions affords powerful supramolecular nanosystems for cutting-edge nanotechnological applications.
Cultivating the passion for amphiphilic cyclodextrins: our scientific runway
Angela Scala;
2022-01-01
Abstract
The development of nanostructured assemblies based on amphiphilic beta-cyclodextrins (aCD) is a crucial step for the fabrication of technological devices with great potential in the diagnosis of various diseases and in delivery of bioactive compounds for therapeutic applications. The synergy between the chemical functionalization of aCD and their typical self-assembly behavior and drug binding abilities has been fruitfully employed, during our ten-years scientific runway, for the development of potential diagnostic tools, sensors and drug delivery systems. Specifically, nanoassemblies based on properly functionalized aCD have been proposed for efficient delivery of anticancer drugs and/or phototherapeutics.[1-4] More recently, the great potential of hybrid aCD nanoassemblies bearing plasmonic or magnetic features has been exploited for controlled release of dopamine [5] and for selective amyloid beta recognition and fishing,[6] respectively. An overview of our most relevant aCD-based supramolecular systems will be presented pointing out that a proper combination of chemical functionalization, nanoassembly decoration and host guest interactions affords powerful supramolecular nanosystems for cutting-edge nanotechnological applications.Pubblicazioni consigliate
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