Background CodY is a highly conserved global transcriptional regulator of metabolic genes in low-G+C Gram-positive bacteria. As its activity is dependent on its interaction with branched-chain amino acids (BCAA) and GTP (except for Lactococcus and Streptococcus species), this regulator controls gene expression in response to the nutritional status of the cell. In pathogens, CodY links nutrient availability with the concerted regulation of metabolism and virulence. Here, we investigated the role of CodY in Group B Streptococcus (GBS), a harmless commensal of the intestinal and urogenital tracts of healthy adults that is responsible of severe, invasive infections in neonates and immunocompromised subjects.

04699 The CodY global regulator controls metabolism and virulence in Group B Streptococcus

Germana Lentini;Carmelo Biondo;Concetta Beninati;
2022

Abstract

Background CodY is a highly conserved global transcriptional regulator of metabolic genes in low-G+C Gram-positive bacteria. As its activity is dependent on its interaction with branched-chain amino acids (BCAA) and GTP (except for Lactococcus and Streptococcus species), this regulator controls gene expression in response to the nutritional status of the cell. In pathogens, CodY links nutrient availability with the concerted regulation of metabolism and virulence. Here, we investigated the role of CodY in Group B Streptococcus (GBS), a harmless commensal of the intestinal and urogenital tracts of healthy adults that is responsible of severe, invasive infections in neonates and immunocompromised subjects.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11570/3244583
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