Multifunctional hybrid magneto and/or plasmonic nanostructures for biomedical applications

In recent years, multifunctional nanostructures (NSs), combining ether the magnetic or the plasmonic properties of iron oxide or noble nanoparticles (i.e., Ag or Au NPs) have attracted intensive research interest due to their unique properties and wide variety of promising applications including, selective sensors, functional composite materials or for biomedical use. This thesis focuses the attention on the development of new multifunctional hybrid magneto and/or plasmonic nanostructures using suitable biomolecule derivatives as templating or capping agents for the stabilization of hybrid components. Specifically, the carnosine modified with ferrocenyl unit (ferrocenylcarnosine, FcCAR) and the hyaluronic acid modified with β-cyclodextrins (HA-CD) were used as organic template/ligand/capping agent for the preparation of silver nanocluster and for the preparation of magneto and/or plasmonic hybrid nanostructures respectively. The thesis is structured in two chapters. Chapter I reports the synthesis of ferrocenylcarnosine (FcCAR) and its applications as sensing materials in electrochemical analyses and as capping agents for the preparation of silvers nanoclusters. Chapter is articulated in the following sections: • Synthesis of Ferrocenylcarnosine • Preparation of Amphiphilic Silver Nanocluster (FcCAR@Ag NCs) and their evaluation as antimicrobial agents • Modification of Screen-Printed Carbon Electrodes using Graphene Cyclodextrin and Ferrocenyl-Carnosine Chapter II reports the synthesis of hyaluronic acid functionalized with β- cyclodextrin as delivery systems and for the development of magneto and/or plasmonic nanostructures. The chapter II is articulated in the following sections: • Development of HA-CD Drug Delivery System • Mono and Bi-metallic Hybrid HA-CD Drug Delivery System